Journal of Hebei Medical University ›› 2025, Vol. 46 ›› Issue (4): 424-429.doi: 10.3969/j.issn.1007-3205.2025.04.009
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Abstract: Objective To investigate the clinical value of anti-ribosomal P protein(Rib) antibody in childhood systemic lupus erythematosus(cSLE). Methods A retrospective analysis was performed on clinical data from 125 patients with newly diagnosed cSLE (cSLE group) from Apirl 2019 to December 2023 in Hebei Children′s Hospital, 86 patients with non-SLE rheumatic disease (disease control group), and 62 healthy controls. The sensitivity and specificity of anti-Rib antibody and other autoantibodies alone and in combination in the diagnosis of cSLE were compared. The positivity rates of anti-Rib antibodies and other autoantibodies among different groups were compared. Logistic regression analysis was used to analyze the relationship between the high sensitivity of autoantibodies and the occurrence of cSLE in cSLE group, and to further compare the clinical characteristics and laboratory indexes of cSLE children in the positive anti-Rib antibody group and the negative group. Results The sensitivity of anti-Rib antibody in cSLE group was 47.2%, which was significantly higher than that of disease control group and healthy control group. The sensitivity of anti-nucleosome + anti-Sm + anti-dsDNA + anti-Rib antibody for combined detection was 82.4%, which was significantly higher than that of single detection and anti-nucleosome + anti-Sm + anti-dsDNA. Anti-dsDNA and positive anti-Rib antibodies were independent risk factors for cSLE (P<0.05). In cSLE group, the incidence of lymph node enlargement and skin mucosal damage (rash, hair loss), as well as the positivity rates of anti-nucleosome and anti-histone antibodies,was significantly higher in the positive anti-Rib antibodies group than in the negative anti-Rib antibodies group, suggesting significant difference (P<0.05). Conclusion Anti-Rib antibody may be involved in the pathogenesis of cSLE and is an independent risk factor for cSLE. Combined with anti-dsDNA, anti-Sm and other autoantibodies, it is of great significance for the correct diagnosis of cSLE.When anti-Rib antibody is positive, the incidence of lymph node enlargement and skin mucosal damage in children with cSLE is higher, which is associated with anti-nucleosome and anti-histone antibodies.
Key words: lupus erythematosus, systemic, children, anti-ribosomal P protein antibody 
YAN Hong, JIA Yong-ping, ZHANG Xiao-shuang, MA De-ran, GUO Ying-hui. The clinical value of anti-ribosomal P protein antibody in childhood systemic lupus erythematosus[J]. Journal of Hebei Medical University, 2025, 46(4): 424-429.
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URL: https://xuebao.hebmu.edu.cn/EN/10.3969/j.issn.1007-3205.2025.04.009
https://xuebao.hebmu.edu.cn/EN/Y2025/V46/I4/424