河北医科大学学报

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石家庄高新地区妊娠妇女甲状腺功能正常参考范围的探讨

  

  1. 1. 河北医科大学第四医院内分泌科,河北 石家庄 050011 ; 2. 河北医科大学第四医院产科,河北 石家庄 050011
  • 出版日期:2016-02-25 发布日期:2016-04-27
  • 作者简介:周韦玲( 1989- ),女,江苏东海人,河北医科大学第 四医院医师,医学硕士,从事内分泌疾病诊治研究。

Gestationalage-specificreferenceintervalsformaternalthyroid functioninShijiazhuangGaoxinarea

  1. 1. DepartmentofEndocrinology , theFourthHospitalofHebeiMedicalUniversity ,
    Shijiazhuang 050011 , China ;
    2. DepartmentofObstetrics , theFourthHospitalof
    HebeiMedicalUniversity , Shijiazhuang 050011 , China
  • Online:2016-02-25 Published:2016-04-27

摘要: 目的 建立石家庄高新地区正常妊娠妇女早、中、晚期甲状腺功能正常参考范围。方法 经过严格筛
选得到石家庄高新地区妊娠妇女 120 例和非妊娠期妇女 60 例。检测其甲状腺功能数值,建立妊娠各期特异性血
清游离三碘甲状腺原氨酸(
freetriiodothyronine , FT 3 )、游离甲状腺素( freethyroxine , FT 4 )、血清促甲状腺激素
(
thyroidstimulatinghormone , TSH )正常参考范围。结果 非妊娠期与妊娠期 3 个时期血清 FT 3 、 FT 4 、 TSH 比较
差异有统计学意义( P <0.01 )。与非妊娠期比较:
T1 期 FT 4 升高, TSH 降低( P <0.05 ); T2 期 FT 3 、 TSH 水平降
低( P <0.05 );
T3 期 FT 3 、 FT 4 水平降低( P <0.05 )。与 T1 期比较: T2 期、 T3 期 FT 3 、 FT 4 水平降低, TSH 水平升
高( P <0.05 )。与 T2 期比较:
T3 期 FT 4 水平降低, TSH 水平升高( P <0.05 )。结论 孕期与非孕期甲状腺功能正
常参考范围差异较大,且在不同孕期也存在较大差异。

关键词: 妊娠, 甲状腺功能试验, 参考值

Abstract:  Objective Toestablishthegestationalmonth-specificstage ( firsttrimesterof
pregnancy , secondtrimesterofpregnancy , thethirdtrimesterofpregnancy ) referenceintervals
formaternalthyroidfunctionintheareaofShijiazhuangGaoxinarea.Methods Atotalof120
pregnantwomenand60non-pregnantwomenwereselectedaccordingtothestrictcriteria.The
studymeasuredmaternalthyroidfunction.Thenormalreferenceintervalsofpregnancyspecific
serumfreetriiodothyronine ( FT 3 ), freethyroxine ( FT 4 ), thyroidstimulatinghormone ( TSH )
wereestablished.Results Serum FT 3 , FT 4 , TSHlevelswerequitedifferentbetweennon-
pregnantwomenandpregnantwomen ( P <0.01 ) .Comparingwiththereferenceintervalsfor
maternalthyroidfunctionlevelofnon-pregnantwomen , theserumFT 4 wassignificantlyhigher
andTSH waslowerinthe1sttrimesterofpregnancy ( P <0.05 ); theserumlevelofFT 3 and higherinthe2ndtrimesterofpregnancyand3rdtrimesterofpregnancy ( P <0.05 ) .Comparing
withthereferenceintervalsformaternalthyroidfunctionof2ndtrimesterofpregnancy , the
serum FT 4 waslowerand TSH washigherinthe3rdtrimesterofpregnancy ( P <0.05 ) .
Conclusion Referenceintervalsforthyroidfunction werequitedifferentbetween pregnant
womenandnon-pregnantwomen , anditwasquitedifferentindifferenttrimestersofpregnancy.
TSH werelowerinthe2sttrimesterofpregnancy ( P <0.05 ); theserumFT 3 andFT 4 werelower
inthe3sttrimesterofpregnancy ( P <0.05 ) .Comparingwiththereferenceintervalsformaternal
thyroidfunctionof1sttrimesterofpregnancy , theserumFT 3 andFT 4 werelowerandTSH was

Key words:  pregnancy , thyroidfunctiontests , referencevalues