河北医科大学学报

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甲状腺全切术对甲状旁腺功能的影响

  

  1. 河北医科大学第二医院甲状腺乳腺外科,河北 石家庄 050000
  • 出版日期:2016-10-25 发布日期:2016-11-04
  • 作者简介:严丽( 1977- ),女,河北石家庄人,河北医科大学第二医院副主任医师,医学博士,从事甲状腺疾病诊治研究。

Analysis of the related factors of the effect of total thyroidectomy on parathyroid function

  1. Department of Thyroid and Breast Surgery, the Second Hospital Affiliated to Hebei Medical University, Shijiazhuang 050000, China
  • Online:2016-10-25 Published:2016-11-04

摘要: [摘要] 目的 探讨甲状腺全切术后血钙、血镁、血磷和血清甲状旁腺激素( parathyroidhormone , PTH )水平
的变化及意义。方法 选取甲状腺全切术患者 129 例(甲状腺乳头状癌 82 例,结节性甲状腺肿和甲状腺腺瘤 47
例),监测所有患者术前和术后 30min 、 1d 、 3d 的血钙、血镁、血磷和血 PTH 水平;并分析患者性别、年龄、术前促
甲状腺激素(
thyroidstimulatinghormone , TSH )水平、术中识别甲状旁腺数和病理类型与术后甲状旁腺损伤所致
低钙血症间的关系。结果 不同甲状腺全切术组术后血钙、血镁和 PTH 水平均呈下降趋势,且血钙和血镁水平以
术后 1d 下降最为明显, PTH 水平在术后 30min 即出现明显下降。血钙水平在不同甲状腺全切术组组间、不同时
点间差异有统计学意义( P <0.05 ),在组间·不同时点间交互作用差异无统计学意义(
P >0.05 )。血镁和 PTH 水
平在不同甲状腺全切术组组间、不同时点间以及组间·不同时点间交互作用差异均有统计学意义( P <0.05 )。血
磷在不同甲状腺全切术组组间、不同时点间以及组间·不同时点间交互作用差异均无统计学意义( P >0.05 )。 129
例甲状腺全切术患者中又分为血钙正常亚组 77 例( 59.7% ),低钙血症无症状亚组 31 例( 24.0% ),低钙血症有症
状亚组 21 例( 16.3% )。低钙血症有症状亚组和低钙血症无症状亚组乳头状癌检出率高于血钙正常亚组( P <
0.05 )。血钙正常亚组、低钙血症有症状亚组和低钙血症无症状亚组性别、年龄、术前 TSH 水平以及术中识别甲状
旁腺数差异无统计学意义( P >0.05 )。结论 手术范围和甲状腺癌可能是术后甲状旁腺损伤的影响因素。甲状腺
术后血 PTH 监测较血钙更敏感。甲状腺术后低钙血症多合并低镁血症,补钙同时应补镁。

关键词: 甲状腺全切除术, 甲状旁腺损伤, 低钙血症

Abstract: [
Abstract ] Objective Toassessthevarietyandsignificanceofserumcalcium , magnesium ,
phosphorus , parathyroidhormone ( PTH ), andrelatedclinicalriskfactorsofparathyroidinjury
aftertotalthyroidectomy.Methods One hundred and twenty-nine patients with total
thyroidectomy , consistingof82caseswiththyroidpapillarycarcinomaand47caseswithNodular
goiterandthyroidadenoma , wereretrospectivelystudied.Levelsofserumcalcium , magnesium ,
inorganicphosphorusandPTHbeforeoperationand30minutes , 1d , 3dafteroperationwere
measuredrespectively , andage , gender , preoperativethyroidstimulating hormone (
TSH ),
intraoperativeidentificationofparathyroidglands , pathologicdiagnosiswerecounted.Andthen
therelationshipbetweentheabovefactorsandhypocalcemiawhichaffectedbyparathyroidinjury
afteroperationwereanalyzedrespectively.Results Serumcalcium , magnesiumandPTHlevels
afteroperationintotalthyroidectomypatients werealllowerthanthosebeforeoperation ,
especiallyserumcalciumandmagnesiumlevelsin1dayafteroperationdecreasedsignificantly ,
andserumPTHlevelsdeclinedin30minutesafteroperation.Therewerestatisticallysignificant differencesonserumcalciumlevelsindifferentthyroidectomygroupsordifferenttimepoints
(
P <0.05 ), buttherewasnosignificantinteractionbetweenthetwogroupsatthesametime
P >0.05 ) .Andtherewerealsostatisticallysignificantdifferencesonserum magnesiumandPTH
indifferentgroups , differenttimepointsandtheinteractionbetweenthetwogroups ( P <0.05 ),
whiletherewasnosignificantdifferenceintheinteractionofserum phosphorusindifferent
groupsofallthegroups , betweendifferentpoints , andbetweenthetwogroups ( P >0.05 ) .
Among129caseswithtotalthyroidectomy , 77cases ( 59.7% ) werenormalserumcalcium , 31
cases ( 24.0% ) wereasymptomatichypocalcemia , and21casesweresymptomatichypocalcemia.
Theriskofhypocalcemiathyroidcancerunderwenttotalthyroidectomygroupaftersurgerywas
significantlyhigherthanthatinbenignthyroiddiseasegroup ( P <0.05 ) .Theidentification
numberandtheage , gender , parathyroidsurgerypreoperative TSH levelandpostoperative
hypocalcemiawerenotstatisticallysignificant ( P >0.05 ) .Conclusion Thescopeofoperationand
thyroidcancermaybetheinfluencingfactorsofparathyroidinjuryafteroperation.Afterthyroid
surgery , bloodPTH monitoringismoresensitivethanserumcalcium monitoring.Lowserum
calciumafterthyroidsurgeryisoftenaccompanywithlowserum magnesium , soserumcalcium
supplementneedsserum magnesiumsupplementatthesametime.

Key words: totalthyroidectomy , parathyroidinjury , hypocalcemia