河北医科大学学报

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静脉重复给药联合关节腔内注射氨甲环酸在初次髋关节置换中的应用

  

  1. 1.河北医科大学第三医院关节一科,河北 石家庄 050051；2.华北理工大学基础医学院2015级临床2班，河北 唐山 063200；
    3.河北医科大学第三医院骨病科，河北 石家庄 050051；4.河北医科大学第三医院经济管理处，河北 石家庄 050051
  • 出版日期:2017-07-25 发布日期:2017-07-05
  • 作者简介:白伟侠（1980-），女，回族，河北无极人，河北医科大学第三医院主管护师，医学学士，从事临床护理学研究。

Application of repeated intravenous medicine combined with intraarticular injection of tranexamic acid in primary hip replacement#br#

  1. 1.First Department of Joint Surgery, the Third Hospital of Hebei Medical University， Shijiazhuang
    050051, China; 2.Clinical Class 2, Grade 2015, Basic Medical College of North China University of
    Science and Technology, Tangshan  063200，China; 3.Department of Osteopathy， the Third
    Hospital of Hebei Medical University， Shijiazhuang 050051, China; 4.Department of
    Economic Management， the Third Hospital of Hebei Medical University，
    Shijiazhuang 050051， China
  • Online:2017-07-25 Published:2017-07-05

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摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗观察静脉重复给药联合关节腔内注射氨甲环酸在初次髋关节置换中的应用效果。
〖HTH〗方法〖HTSS〗〖KG*2〗选择初次髋关节置换术患者92例分为试验组和对照组各46例。试验组切皮前静脉滴注15 mg/kg氨甲环酸，术中关节腔注射1.0 g氨甲环酸，术后3 h滴注10 mg/kg氨甲环酸；对照组切皮前静脉滴注15 mg/kg氨甲环酸，术中关节腔注射1.0 g氨甲环酸。术后评估2组并发症、出血量、输血量、血红蛋白、血细胞比容、住院时间。
〖HTH〗结果〖HTSS〗〖KG*2〗术后3 d 2组复查深静脉彩色超声均未发现深静脉血栓形成。2组各有1例输血，输血量均为400 mL。试验组术后出血量少于对照组，术后血红蛋白含量高于对照组，差异有统计学意义(P＜005)；2组术中出血量、术后血细胞比容、住院时间差异无统计学意义（P＞005）。
〖HTH〗结论〖HTSS〗〖KG*2〗静脉重复给药联合术中关节腔内注射氨甲环酸在初次髋关节置换术后出血量较术前静脉滴注联合术中关节腔内注射氨甲环酸出血量明显减少。

关键词: 关节成形术, 置换, 髋, 氨甲环酸, 出血

Abstract: ［Abstract］  Objective〖HTSS〗〓To evaluate the outcome of reduplicative intravenous administration combined with intraarticular injection of tranexamic acid(TXA) in primary total hip arthroplasty(THA).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Total of 92 patients, accepting primary total hip arthroplasty, were divided into experiment group(intravenous administration of TXA 15 mg/kg before incision, intraarticular injection of TXA 1.0 g intraoperation, intravenous administration of TXA 10 mg/kg 3 hours postoperation, n=46) and, control group (intravenous administration of TXA 15 mg/kg before incision, intraarticular injection of TXA 1.0 g intraoperation, n=46）. Postoperative evaluation index include bleeding volume, transfusion volume and complications as well as variation of hemoglobin and blood volume, erythrocrit, and hospital stays.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Three days after operation, no deep venous thrombosis(DVT) was found among all patients through ultrasounds. Both experiment group and control group have one patient receving transfusion with the volume of 400 mL. There was no significant difference between the two groups in intraoperative bleeding volume, haematocrit and hospital stay. However significant differences were found in postoperative bleeding volume and hemoglobin content between the two groups(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓〖JP2〗Postoperative bleeding volume was significantly decreased in primary THA with reduplicative intravenous administration combined with intraarticular injection of TXA.

Key words: arthroplasty, replacement, hip, tranexamic acid, hemorrhage

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