信号转导与转录激活因子3、细胞周期素D1在胆管癌组织中的表达及意义

doi:10.3969/j.issn.10073205.2017.12.009

河北医科大学学报

信号转导与转录激活因子3、细胞周期素D1在胆管癌组织中的表达及意义

1.河北医科大学第二医院肝胆外科，河北石家庄 050000；2.河北医科大学第三医院肿瘤科，河北石家庄 050051

出版日期:2017-12-25 发布日期:2017-12-19
作者简介:王文斌（1973-），男，河北保定人，河北医科大学第二医院副主任医师，医学博士，从事肝胆外科疾病诊治研究。

The expression and clinical significance of STAT3 and Cyclin D1 in cholangiocarcinoma#br#

1.Department of Hepatobiliary Surgery, the Second Hospital of Hebei Medical University, Shijiazhuang
050000, China； 2.Department of Oncology, the Third Hospital of Hebei
Medical University, Shijiazhuang 050051, China

Online:2017-12-25 Published:2017-12-19

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗检测信号转导与转录激活因子3（signal transducer and activator of transcription 3，STAT3）、细胞周期素D1（Cyclin D1）在胆管癌组织中的表达并分析其临床意义。
〖HTH〗方法〖HTSS〗〖KG*2〗采用免疫组织化学技术检测STAT3、Cyclin D1在70例胆管癌组织和15例非肿瘤胆道上皮组织中的表达情况。
〖HTH〗结果〖HTSS〗〖KG*2〗免疫组织化学结果显示70例胆管癌组织和15例非肿瘤胆道上皮组织中STAT3、Cyclin D1阳性表达率分别为61.4%、33.3%和42.9%、13.3%。STAT3、Cyclin D1蛋白在胆管癌组织中的表达均明显高于非肿瘤胆道上皮组织（P＜005）。STAT3蛋白表达与胆管癌的临床分期、淋巴结转移和组织学分级明显相关（P＜005）；胆管癌组织中Cyclin D1蛋白表达与淋巴结转移和组织学分级明显相关（P＜005）。STAT3与Cyclin D1表达呈明显正相关关系（P＜005）。STAT3、Cyclin D1蛋白共阴性表达组生存时间明显长于共阳性表达组(P＜001)。
〖HTH〗结论〖HTSS〗〖KG*2〗STAT3、Cyclin D1可能是反映胆管癌发生发展的重要生物学指标。

关键词: 胆管肿瘤, 转录激活因子3, 细胞周期素D1

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the expression and clinical significance of signal transducer and activator of transcription 3（STAT3 ） and Cyclin D1 in cholangiocarcinoma tissues.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Immunohistochemical staining was used to detect the expression of STAT3 and Cyclin D1 in 70 cases of cholangiocarcinoma and 15 cases of nontumor bile duct epithelium.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The expression of STAT3 and Cyclin D1 in cholangiocarcinoma(61.4%, 42.9%) was significantly higher than that in nontumor bile duct epithelium(33.3%, 13.3%)(P＜005). STAT3 expression significantly correlated with clinical stage, lymph nodes metastasis and tumor grade. The positive rates of STAT3 was significantly higher in the stage Ⅲ+Ⅳ group , lymph nodes metastasis group and moderately or poorlydifferentiated group than those in stageⅠ+Ⅱ group, no lymph nodes metastasis group and welldifferentiated group(P＜005). Cyclin D1 expression was significantly correlated with lymph nodes metastasis and tumor grade. The positive rates of Cyclin D1 was significantly higher in the lymph nodes metastasis group and moderately or poorlydifferentiated than those in no lymph nodes metastasis group and welldifferentiated. A significant correlation was found between the expressions of STAT3 and Cyclin D1 in cholangiocarcinoma(P＜005). The survival time of negative expression of STAT3 and Cyclin D1 group was longer than that of positive expression of STAT3 and Cyclin D1 group(P＜001).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓STAT3 and Cyclin D1 may be important biomarkers in carcinogenesis and progression of cholangiocarcinoma.

Key words: bile duct neoplasms, activating transcription factor 3； Cyclin D1

王文斌1，刘〓兵2，王天阳1，吕海涛1，刘学青1. 信号转导与转录激活因子3、细胞周期素D1在胆管癌组织中的表达及意义[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2017.12.009.

WANG Wenbin1, LIU Bing2, WANG Tianyang1, LYU Haitao1, LIU Xueqing1. The expression and clinical significance of STAT3 and Cyclin D1 in cholangiocarcinoma#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2017.12.009.

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信号转导与转录激活因子3、细胞周期素D1在胆管癌组织中的表达及意义

The expression and clinical significance of STAT3 and Cyclin D1 in cholangiocarcinoma#br#

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