Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the influencing factors of refractory tuberculous meningitis.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Ninetynine patients with tuberculous meningitis were divided into ordinary tuberculous meningitis group and refractory tuberculous meningitis group. The clinical features, cerebrospinal fluid index, image credits, antituberculosis drugs, hormone application and vertebral canal injection medicin were analyzed of 2 groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Univariate analysis showed that disease progression(>3 months), applied antituberculosis drugs outside the hospital, difference of antituberculosis program, cerebrospinal fluid indicators(number of cells, chlorine value, adenosine deamianse), meninges strengthening in the 2 groups of patients were significantly different(P＜005). The results of Logistic regression analysis showed that prehospital antituberculosis treatment and chloride<120 mmol/L, antituberculosis program were the influencing factors of tuberculous meningitis.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Low chlorine of cerebrospinal fluid is an independent predictor of refractory tuberculous meningitis, the strength of the chemotherapy scheme has a great influence on tuberculous meningitis.

Key words: tuberculosis, meningeal, root cause analysis, treatment outcome