Abstract: Objective  To observe the clinical application of recombinant human granulocyte macrophage colony stimulating factor(rhGM-CSF) gel combined with functional dressings for sequential treatment of medium-thickness skin donor site wounds.
Methods  A total of 78 patients with medium-thickness skin grafts were randomly divided into experimental group and control group. The skin donor area of the experimental group was treated with rhGM-CSF gel, and combined with alginate dressing and lipid hydrocolloid dressing to repair the wound on the second day after surgery. The control group used traditional petroleum jelly gauze and sterile dressing on the second postoperative day to cover and repair the wound. The postoperative wound infection, dressing change pain score, wound dressing frequency and comfort, wound healing time, and wound healing effect were compared between two groups.
Results  ①The healing time and the number of dressing changes in the experimental group were shorter or lower than those in the control group(P＜0.05). ②The pain grade of dressing change in the experimental group was significantly lower than that in the control group(P＜0.05). ③The patient comfort and wound healing quality of the experimental group were higher than those in the control group, while nursing difficulty and wound infection rate were lower than those of control group(P＜0.05).
Conclusion  The rhGM-CSF gel combined with alginate and lipid hydrocolloid dressings can be used on the wound surface of the medium-thickness skin donor site, which can reduce the infection rate of the wound surface, alleviate the pain, improve the comfort and the quality of wound healing, and the clinical effect is ideal.

Key words: granulocyte-macrophage colony-stimulating factor, dressings, hydrocolloid, treatment outcome