Abstract: ［Abstract］ Objective〖HTSS〗〓Owing to the curative effect of ulinastatin to paraquat poisoning is uncertain, we conducted the Metaanalysis about the effection of ulinastatin on patients of paraquat poisoning.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The studies about paraquat poisoning and ulinastatin were searched by the PubMed, Embase, The Cochrane Library, CNKI, VIP and the WANFANG data base，and the studies that are inconsistent with the included standards were deleted. Subsequently, we made the bias risk assessment, included in the Revman 5.3, to assess the evidence of randomized controlled trial(RCT). And the Newcastle Ottawa Scale is used to evaluate the evidence of nonRCT. Afterwards, we calculated the Odd Ratios(OR), standardized mean difference(SMD) and 95% confidence intervals(CI) by random or fixed effects model. And we mapped the forest graphs, Funnel Graphs with the Revman 5.3 software. The evaluation results include the effects between statin group and control group and the mortality rate of acute lung injury/acute respiration distress syndrome(ALI/ARDS), pulmonary fibrosis, respiratory failure, multiple organ dysfunction syndrome(MODS) the incidence rate of change, and inflammatory cytokines interleukin 6(IL6) changes.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Nine RCT and 6 nonRCT studies were chosen in the meta analysis, which involved 1 133 paraquat poisoning patients. There are 589 patients about ulinastatin group and 544 patients about control group in the meta analysis. And the results of the meta analysis were as followings: the main outcome is mortality/the incidence of inefficiency, and the incidence is less than the control group(OR=0.41，95%CI=0.31~0.55), P＜001). The incidence of MODS is less than control group(OR=0.52， 95%CI=0.37~0.72, P＜001). The change of inflammation cytokine IL6 is more  obvious than control group(SMD=1.32， 95%CI=0.94~1.71, P＜001).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Ulinastatin, which has effective affects in increasing the descent range of  the inflammation cytokine IL6, decreasing the mortality and reducing the incidence of MODS, is more beneficial than the glucocorticoid alone.

Key words: paraquat, poisoning； ulinastatin； Metaanalysis