Abstract: ［Abstract］〓Objective〖HTSS〗〓To compare two different content determination methods of pramipexole hydrochloride.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The potentiometric titration method and high performance liquid chromatography(HPLC)method were used to measure the content of Pramipexole Hydrochloride.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The results of titration and HPLC method are basically consistent, The relative standard deviation of potentiometric titration is smaller than that of HPLC, and the deviation of HPLC is higher than that of titration, and the repeatability of titration is better, so the potentiometric titration method should be a top priority.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The titration method is simple, fast, low cost, has high precision and good accuracy, and it is suitable for measuring the content of pramipexole hydrochloride.

Key words: pramipexole hydrochloride, potentiometric titration, chromatography, high pressure liquid