Abstract: ［Abstract］〓Objective〖HTSS〗〓To observe the effects of allopurinol on serum uric acid(SUA) and urinary protein excretion of diabetic nephropathy(DN) patients with hyperuricemia.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and sixty DN patients with hyperuricemia were included in this study. They were randomly divided into control group(80 cases) and allopurinol group(80 cases). Two groups of patients were given the conventional treatment of diabetes. The control group were given placebo and the treatment group were given allopurinol. 24 hour urine protein quantitative(UTP), urinary albumin excretion rate（UAER）, SUA， highsensitivity Creactive protein(hsCRP), potassium， serum creatinine(SCr)， blood glucose were detected before and after treatment. 
〖HTH〗〖WTHZ〗Results〖HTSS〗〓UTP, UAER, hsCRP, SUA of the patients in the two groups after treatment were decreased, and  UTP, UAER, hsCRP and SUA in treatment group were lower than those in control group, the difference was statistically significant（P＜005）. After treatment, there was no significant difference in the SCr, potassium and GLU between 2 groups and the 2 groups before and after treatment（P＞005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Allopurinol can effectively reduce urinary albumin excretion rate in diabetic nephropathy patients with hyperuricemia. The mechanism may be related to reduce urinary protein excretion through the effects of uric acid and insulin resistance, so as to protect renal function early.

Key words: diabetic nephropathies, hyperuricemia, allopurinol