Abstract: Objective To analyze the relationship between thyroid hormone level and hyperuricemia (HUA) in patients with diabetic nephropathy (DKD). 
Methods A total of 102 patients with DKD treated in the hospital were selected. Patients were divided into occurrence group (n=50) and non-occurrence group (n=52) according to presence of HUA. The baseline data and laboratory indexes of the two groups were analyzed. Pearson bivariate correlation and Logistic regression were used to analyze the relationship between thyroid hormone level and HUA in patients with DKD. 
Results Among 102 patients with DKD, 50 patients developed HUA, with an incidence rate of 49.02%. The levels of serum uric acid, triacylglycerol (TG) and thyroid stimulating hormone (TSH) in the occurrence group were higher than those in the non-occurrence group, while the levels of free triiodothyronine (FT3) and free thyroxine (FT4) were lower than those in the non-occurrence group (P＜0.05). There was no significant difference in other baseline data and laboratory indexes between groups (P＞0.05). Pearson bivariate correlation analysis was used, and the results showed that the level of serum uric acid was positively correlated with the levels of blood lipid and TSH in patients with DKD (P＜0.05), while the level of serum uric acid was negatively correlated with the levels of FT3 and FT4 in patients with DKD (P＜0.05). Logistic regression analysis showed that the levels of TSH, FT3 and FT4 were related to the occurrence of HUA in patients with DKD (P＜0.05). 
Conclusion Thyroid hormone levels are associated with HUA in patients with DKD. 

Key words: diabetic nephropathies, hyperuricemia, thyroid hormones