Abstract: ［Abstract］〓Objective〖HTSS〗〓To set up the animal model of obstructive sleep apneahypopnea syndrome(OSAHS) in male NewZealand rabbit, and to observe the effect of the testis and the spermatozoa in cauda epididymis under OSAHS，so that to provide theoretical bases for the preventation of sterility caused by OSAHS.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Twenty male NewZealand white rabbits were randomly divided into two groups and ten rabbits in each. Two groups were obstructive sleep apneahypopnea syndrome group(group OSAHS) and control group. A total of 2 mL polyacrylamide hydrogel were injected into rabbit soft palate of group OSAHS to set up OSAHS animal models. After sleep for 8 weeks by dorsal position, all the animals were killed and the testis were observed  under the transmission electron microscope and the AX80 universal microscope. The left cauda epididymis was obtained to be observed the number, viability, motility rate and abnormal rate of spermatozoa. The SPSS 13.0 software was used to analyse. 〖HTH〗〖WTHZ〗Results〖HTSS〗〓Transmission electron microscope and the light microscope revealed that the spermatogenic cell, the seminiferous tubule and the spermatogenic epithelium were damaged in the group OSAHS. In OSAHS group animals, the number, viability rate and motility rate of spermatozoa in cauda epididymis were significantly decreased while the rate of teratospermia was increased(P＜0.05). The saturation of blood oxygen and the rate of teratospermia were negatively correlated by the correlation analysis.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The damage of spermatogenic cells and the decrease of the sperm quality were caused by hypoxia which was caused by OSAHS.

Key words: sleep apnea, obstructive； urogenital system, rabbit