Abstract: ［Abstract］ Objective〖HTSS〗To investigate the effects of propofol on the expression of nuclear factor-κB(NF-κB） and the inflammatory response and apoptosis in the traumatic hemorrhagic shock resuscitation-gastric mucosal injury （THSR-GMI） in rabbits, and to clarify the effects of propofol on THSR-GMI.
  〖WTHZ〗Methods〖HTSS〗Seventy-five New Zealand healthy adult male rabbits were randomly divided into 5 groups, 15 rabbits in each group: control group（group S）, model group（group M）, pro-ischemia group（group P1）, pro-resuscitation group（group P2） and post-resuscitation group（group P3）. The traumatic hemorrage resuscitation-gastric mucosal injury model was established. In group P1, group P2 and group P3, propofol 5mg/kg was injected intravenously 10 min before ischemia, resuscitation and 20 min at resuscitation repectively, then propofol 20 mg·kg-1·h-1 was infused. In group S and group M, propofol was replaced with equal volume of normal saline. After 90 minutes of resuscitation, the venous blood and gastric tissue samples were taken, and the degree of gastric mucosa injury was observed with naked eyes. The damage index(DI) of gastric mucosa was calculated under magnifying glass, and the polymorphonuclear leukocyte(PMN) were counted under light microscope. The expression of apoptosis index(AI) and NF-κB in gastric mucosa were measured by terminal deoxynucleotidyl transferase-mediated dUTP incision end labeling(TUNEL) and immunohistochemistry, respectively. Serum tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were measured by enzyme linked immunosorbent assay concentration.
  〖WTHZ〗Results〖HTSS〗Compared with group S, the gastric mucosa were damaged in different degrees, and the DI, PMN counts, AI and the expression of NF-κB in the gastric mucosa, and the serum levels of TNF-α and IL-6 were significantly increased （P＜0.05） in group M, P1 , P2 and P3. Compared with group M, the gastric mucosal injury was alleviated in varying degrees, and the DI, PMN counts, AI and the expression of NF-κB in the gastric mucosa, and the serum levels of TNF-α and IL-6 were obviously decreased（P＜0.05） in group P1 , P2 and P3. Compared with group P3, the gastric mucosal injury was relieved, and the DI, PMN counts, AI and the expression of NF-κB in the gastric mucosa, and the serum levels of TNF-α and IL-6 were obviously decreased（P＜0.05）in group P1.
  〖WTHZ〗Conclusion〖HTSS〗Propofol can decrease NF-κB expression, inhibit inflammatory response and apoptosis, so as to reduce gastric mucosal injury after traumatic hemorrhagic shock and resuscitation in rabbits, and the effect of propofol is better before bleeding.

Key words: shock, hemorrhagic, nuclear factor-κB, propofol, rabbits