Abstract: ［Abstract］ObjectiveTo explore the effect of Sitagliptin combined with Voglibose in the treatment of type 2 diabetes mellitus and its expression on serum level of irisin and Nesfatin-1.
〖WTHZ〗MethodsA total of 164 cases of type 2 diabetes mellitus patients who were treated in our hospital were selected as the observation subjects. They were divided into the control group and the observation group according to the random envelope method, 82 cases in each group. The control group was treated with Voglibose, and the observation group was treated with Sitagliptin and Voglibose. Blood glucose(FBG, 2 hPG, HbA1c, FINS), blood lipids(TG, TC, LDL-C, HDL-C), insulin resistance index HOMA-IR, clinical efficacy, serum irisin and Nesfatin-1 levels and adverse reactions were compared and analyzed.
〖WTHZ〗ResultsAfter treatment, FBG, HbA1c, 2hPG and HOMA-IR in the two groups were significantly lower than those of the observation group. HPG and HOMA-IR were lower than those of the control group(P＜0.01).The levels of TC, TG and LDL-C in the two groups were significantly lower than that of the control group, And the levels of HDL-C in the observation group were significantly higher than that of the control group(P＜0.01). The clinical effect of the observation group was better than that of the control group, and the total effective rate was significantly higher than that of the control group(P＜0.01). The level of serum nesfatin-1 in the two groups was significantly lower than that of the control group, and the level of serum irisin in the observation group was significantly lower than that of the control group, and the level of serum irisin was significantly higher than that of the control group(P＜0.01). There was no significant difference in the incidence of adverse reactions(P＞0.05).
〖WTHZ〗ConclusionSitagliptin combined with Voglibose in the treatment of type 2 diabetes mellitus can effectively improve the clinical efficacy, optimize the level of lipid metabolism, up-regulate the level of serum irisin, reduce the concentration of serum Nesfatin-1, it is safe and effective, and it is worth promoting.

Key words: diabetes mellitus, type 2；sitagliptin, voglibose