Abstract: ［Abstract］ ObjectiveTo observe the changes of glomerular filtration rate(eGFR) in hospitalized type 2 diabetes mellitus patients with different age and weight,and analyze the relationship between metabolic parameters with it.
〖WTHZ〗MethodsTwo hundred and seven diabetics and 68 non-diabetics information was collected. The eGFR was calculated by the modified MDRD formula. The differences of eGFR between each group were analyzed by multiple comparisons and the correlation between eGFR and other metabolic parameters was analyzed. Linear regression analysis was carried out. Further, the patients aged 40-70 were divided into different body mass index(BMI) groups to analyze the differences between the groups.
〖WTHZ〗ResultsWith the increase of age, BMI, glutaminc oxalacetic transaminase(AST）, glutamic pyruvic transaminase（ALT），  uric acid（UA）  and eGFR decreased.There was significant difference in eGFR among age groups(P＜0.001). Pearson correlation analysis showed that eGFR was positively correlated with BMI, triglyceride(TG), ALT, AST, gamma-glutamyl transpeptidase(GGT), UA, and negatively correlated with gender, homocysteine(HCY), hemoglobin A1c(HbA1c), 25 hydroxyvitamin D25(OH)D. Further linear regression analysis showed that BMI, TG, ALT  were positively correlated with eGFR(P＜0.001), and AST, GGT, UA, HbA1c, Hcy, 25(OH) D  were negatively correlated with it(P＜0.001). Patients of similar age were divided into different BMI groups. With the increase of BMI, eGFR increased gradually. There was significant difference in eGFR between obese group and normal weight group(P＜0.001). The difference of eGFR among severly obese and other groups was statisically significant(P＜0.001).
〖WTHZ〗ConclusionWith the increase of age, the metabolic level and eGFR of type 2 diabetic patients decrease. AST, 25（OH） D, UA and HCY are independent risk factors of renal injury. The obese patients have high levels of eGFR, as patients of similar ages.

Key words: diabetes mellitus, type 2, obesity, glomerular filtration rate