Abstract: ［Abstract］ObjectiveTo explore the effect of endovascular intervention therapy on fibrinogen(FIB), homocysteine(HCY) level and prognosis of acute ischemic stroke.
〖WTHZ〗MethodsA total of 60 patients with acute ischemic stroke receiving intravascular interventional therapy were selected as the observation group, and 60 patients receiving intravenous thrombolysis were selected as the control group. The National Institute of Health stroke scale(NIHSS) score, recanalization score, FIB and HCY level, and Glasgow Outcome scale(GOS) score were compared between two groups before, immediately after and 10 d after thrombolysis.
〖WTHZ〗ResultsNIHSS score, FIB and HCY levels in the 2 groups showed a trend of decrease, recanalization score, GOS score showed a trend of increase, observation group NIHSS score, FIB and HCY levels to reduce the amplitude was greater than the control group, recanalization rate high, GOS score was greater than the control group, between groups, between point, between groups, interaction between point difference was statistically significant(P＜0.05 or P＜0.01).
〖WTHZ〗ConclusionIntravascular interventional therapy can improve the symptoms of neurological defects in patients with acute ischemic stroke, improve the vascular recanalization rate, reduce the levels of FIB and HCY, and improve the prognosis.

Key words: stroke, endovascular interventional therapy, intravenous thrombolysis