Abstract: ［Abstract］ Objective〖HTSS〗To investigate the clinical effect of Kangfuxin liquid combined with lidocaine assisted oxygen therapy on recurrent oral ulcer.
〖WTHZ〗Methods〖HTSS〗A total of 107 patients with recurrent oral ulcer were randomly divided into control group(53 cases) and study group(54 cases) by random number table method. The control group was treated with lidocaine and oxygen therapy, while the study group was treated with Kangfuxin solution, lidocaine and oxygen therapy. The pain relief degree of the two groups was compared 6 days after treatment. Six days after the treatment, the cure rate of the two groups was compared, the levels of CD3+, CD4+, CD8+, IL-6 and TNF-α were compared, and the recurrence and adverse reactions of the two groups were followed up.
〖WTHZ〗Results〖HTSS〗After treatment, the pain index of the study group was lower than that of the control group, the healing time was shorter than that of the control group, the total effective rate was higher than that of the control group, the levels of CD3+, CD4+ and CD4+/CD8+ were higher than that of the control group, the levels of TNF-α and IL-6 were lower than that of the control group, and the recurrence rate was lower than that of the control group(P＜0.05 or P＜0.01). There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).
〖WTHZ〗Conclusion〖HTSS〗The treatment of recurrent oral ulcer with Kangfuxin liquid combined with lidocaine adjuvant oxygen therapy can enhance the efficacy, relieve pain, improve the immune function, reduce the inflammatory response, reduce the recurrence rate, and have fewer adverse reactions.

Key words: oral ulcer, lidocaine, kangfuxin liquid