Abstract: Objective  To observe the clinical efficacy of pancreatic kininogenase enteric coated tablets combined with beraprost sodium in the treatment of type 2 diabetes mellitus(T2DM) with lower extremity artery stenosis.
Methods  Sixty patients with type 2 diabetes mellitus complicated with anterior tibial artery, posterior tibial artery and peroneal artery stenosis were included in the study, and they were randomly divided into observation group and control group. Both groups were strictly controlled blood glucose and anti arteriosclerosis treatment. The control group was treated with beraprost sodium alone. The observation group: orally taking beraprost sodium, combined with pancreatic kininogenase enteric coated tablets. The maximum walking distance, painless walking distance, ankle brachial index(ABI), peak systolic blood flow velocity(PSV) and diameter stenosis rate were recorded before and after treatment in the two groups.
Results  After treatment, the painless walking distance, maximum walking distance and ABI of the two groups were significantly higher than those before treatment(P＜0.05); After treatment, the painless walking distance, maximum walking distance and ABI of the observation group were significantly higher than those of the control group(P＜0.05). After treatment, PSV of anterior tibial artery, posterior tibial artery and peroneal artery in the two groups were significantly reduced, and the stenosis rate of diameter was significantly lower than that before treatment(P＜0.05), and after treatment, PSV of each artery in the observation group was significantly slower than that in the control group, and the diameter stenosis rate was significantly lower than that in the control group(P＜0.05).
Conclusion  Pancreatic kininogenase enteric coated tablets combined with beraprost sodium can more effectively improve the maximum walking distance, painless walking distance and ABI index in patients with type 2 diabetes mellitus complicated with lower extremity artery stenosis. The mechanism may be related to that the combination of pancreatic kininogenase enteric coated tablets and beraprost sodium can more effectively reduce the peak blood flow velocity, reduce the stenosis rate of vascular diameter and improve the lower limb ischemia.

Key words: diabetes mellitus, type 2, tibial arteries, diabetes complications