Abstract: Objective  To study the dependency between paraoxonase-1(PON1), HtrA serine peptidase 4(HtrA4) and the efficacy of Labe in the treatment of preeclampsia complicated with metabolic syndrome.
  Methods  A totla of 114 patients of preeclampsia  of gynecology and obstetrics were divided into preeclampsia without metabolic syndrome group(n=42) and preeclampsia with metabolic syndrome group(n=72). Normal pregnant women who were examined in our hospital at the same time were selected as normal pregnancy group(n=50). The clinical data, the levels of serum PON1 and HtrA4 before and after treatment of the three groups were compared. According to the therapeutic effect, the patients of preeclampsia with metabolic syndrome group were divided into three groups: obvious effective, effective and ineffective,the serum levels of PON1 and HtrA4 before and after treatment were compared, and the correlation test was carried out.
  Results  Before the treatment, patients′ serum PON1 level in preeclampsia with metabolic syndrome group was lower than that of preeclampsia without metabolic syndrome and normal pregnancy group, serum HtrA4 level higher than that of preeclampsia without metabolic syndrome group and normal pregnancy group（P＜0.05）. Patients′ serum PON1 level in preeclampsia without metabolic syndrome group was lower than the normal pregnancy group, serum HtrA4 level higher than that of normal pregnancy group(P＜0.05). After treatment, patients′ serum PON1 level in preeclampsia with the metabolic syndrome group and preeclampsia without metabolic syndrome group was higher than the level before the treatment, serum HtrA4 level was lower than the level before treatment(P＜0.05). The patients′ serum PON1 level in the preeclampsia with metabolic syndrome group was lower than that of preeclampsia without metabolic syndrome group, serum HtrA4 level was higher than that of preeclampsia without metabolic syndrome group(P＜0.05). After treatment, in the group of preeclampsia with metabolic syndrome, there were 28 cases with obvious effective curative effect, and 36 cases with effective curative effect and 8 cases with ineffective curative effect. After treatment,serum PON1 level in the obvious effective group, effective group and ineffective group was higher than that before treatment, serum HtrA4 level was lower than that before treatment, PON1 level in the effective group was higher than that in the effective group and ineffective group. Serum PON1 level in the effective group was higher than that in the ineffective group, and serum HtrA4 level was lower than that in the ineffective group(P＜0.05).PON1 level was positively correlated with clinical curative efficacy, while HtrA4 level was negatively correlated with clinical efficacy(P＜0.05).
  Conclusion  Serum PON1 and HtrA4 are both involved in the occurrence of preeclampsia complicated with metabolic syndrome and are correlated with the clinical efficacy of Labe therapy.They may be the new biological index to evaluate the therapeutic effect of preeclampsia combined with metabolic syndrome.

Key words: eclampsia； metabolic syndrome； paraoxonase-1, htrA serine peptidase 4