Abstract: Objective To analyze the effect of human corneal stroma lens from femtosecond laser small incision lenticule extraction（SMILE）sources in corneal ulcer. 
Methods Seventy-five patients with corneal ulcer were selected as the main subjects.It was randomly divided into observation group(38 cases) and control group(37 cases). SMILE source of human corneal stroma lens combined with amniotic membrane transplantation was used in the observation group. To observe the therapeutic effect of the two groups, At the same time, the difference of visual acuity between two groups was compared, and the incidence of postoperative complications was calculated. 
Results The total effective rate in the observation group was 97.37%, which was significantly higher than that in the control group(P＜0.05). After operation, the difference of visual acuity were not statistically significant between two groups(P＞0.05). After operation, the incidence of postoperative complications was 2.63% in the observation group, which was significantly lower than that in the control group(P＜0.05). 
Conclusion Human corneal stromal lens from SMILE sources has good therapeutic effect in corneal ulcer, can effectively improve the postoperative visual condition of patients, and has high safety, which is worth popularizing.

Key words: corneal ulcer, treatment outcome； corneal stroma