Abstract: Objective  To assess the plantar pressure changes and correlating risk factors in the patients with type 1 diabetes(T1DM). 
Methods  A total of 40 patients with T1DM were recruited in this study. Plantar pressure was obtained from 10 foot regions at enrollment and two years later. Additionally, some relevant clinical data were recorded. 
Results  Over the course of 2 years, significant plantar pressure increase in the second and third metatarsal heads was found(P＜0.05). Decrease of impulse under the medial and lateral side of the heel and pressure time integral under the lateral side of the heel were also identified(P＜0.05). The increase of plantar pressure in the second and third metatarsal heads and under the medial and lateral side of the heel was correlated with increased serum total cholesterol(TC)(β=0.336-0.495， P＜0.05). The increase of plantar pressure in the second and third metatarsal heads was correlated with the appearance of calluses during the study period(β=0.259-0.448， P＜0.05). In addition, the increase of plantar pressure in the second metatarsal head was correlated with the change of hemoglobin A1c(β=0.248-0.320， P＜0.05). The increase of maximum pressure in the second metatarsal head was correlated with the change of sensory nerve conduction velocities(SCV) (β=-0.327， P=0.026). 
Conclusion  With the prolongation of the disease course, the plantar pressure of the second and third metatarsal heads among the patients with T1DM was increased significantly. The increase of plantar pressure was correlated with the changes of serum TC level, hemoglobin A1c, SCV and the appearance of calluses.

Key words: diabetes mellitus, type 1, plantar pressure； risk factor