Abstract: Objective  To explore the value of ropivacaine hydrochloride combined with hydromorphone fine needle spinal anesthesia in cesarean section. 
Methods  A total of 80 cases of cesarean section women were selected as the research object, and they were divided into observation group and control group by random number method, with 40 cases each. The control group was treated with ropivacaine fine needle spinal anesthesia, and the observation group was combined with oxymorphone fine needle spinal anesthesia on the basis of the control group. The perioperative indicators(operation time, delivery time, anesthesia dose, infusion volume, postpartum hemorrhage volume) and anesthesia effect of the two groups of maternal patients were compare. The visual analogue pain(VAS) score and sedation(Ramsay) score of the two groups at different times were compared. And the difference of pain stress factors［substance P(SP), neuropeptide Y(NPY), nerve growth factor(NGF) and prostaglandin E2(PGE2)］ before and after surgery were compared. And finally the adverse reactions of the two groups were counted. 
Results  There were no significant differences in the operation time, delivery time, anesthesia dose, infusion volume, and postpartum hemorrhage in the observation group compared with the control group(P＞0.05). The good rate of anesthesia in the observation group was significantly higher than that in the control group, and the difference was statistically significant(P＜0.05). The VAS scores in the two groups were compared after operation, the difference was statistically significant(P＜0.05). The observation group scores were significantly lower than the control group at 12 h and 18 h after operation, the difference was statistical significance(P＜0.05); within two groups of Ramsay score comparisons were significantly higher after surgery, the difference was statistically significant(P＜0.05). There was statistical significance between time points(P＜0.05), but there was no significant difference in interaction between groups and time points(P＞0.05). The postoperative SP, NPY and PGE2 in the observation group were significantly higher than those in the preoperative group and lower than those in the control group. The differences were statistically significant(P＜0.05). Compared with the two groups before and after surgery, the NGF increased significantly with a statistically significant difference(P＜0.05). There was no significant difference between the two groups before and after NGF surgery(P＞0.05). The total incidence of adverse reactions was not statistically significant between two groups(P＞0.05). 
Conclusion  Ropivacaine hydrochloride combined with hydromorphone fine needle spinal anesthesia can be used in cesarean section to improve the effect of anesthesia, reduce maternal pain and stress reactions without increasing the incidence of adverse reactions.

Key words: cesarean section, ropivacaine hydrochloride, hydromorphone, anesthesia, spinal