Abstract: Objective  To explore the clinical effect of combined use of liraglutide and ticagrelor in the treatment of type 2 diabetes mellitus(T2DM) complicated by coronary heart disease(CHD) and its effect on serum visceral adipose tissue-derived serine protease inhibitor(Vaspin) and growth hormone releasing peptide Ghrelin. 
Methods  A total of 114 patients with T2DM and CHD diagnosed in our hospital were selected and divided into a control group(n=57) and an observation group(n=57) by random number grouping. The control group was given ticagrelor and metformin hydrochloride, and the observation group was given ticagrelor and liraglutide. The clinical efficacy, blood lipids, blood glucose, cardiac function, levels of serum endothelial cell-associated factors Vaspin and Ghrelin before and after treatment and the incidence of adverse reactions were compared between two groups. 
Results  The effective rate of the observation group was significantly higher than that of the control group(P＜0.05). After treatment, the blood glucose levels of the two groups were significantly lower than before treatment(P＜0.05), and there was no significant difference in blood glucose levels between two groups(P＞0.05). After treatment, the levels of left ventricular eject fraction(LVEF), left ventricular end diastolic dimension(LVEDD), and early/late diastolic mitral flow velocity ratio（E/A） in the control group were improved compared to before treatment, and all indicators of heart function in the observation group were improved compared with before treatment. The indicators of heart function in the observation group improved more significantly than those in the control group(P＜0.05). After treatment, the levels of Ghrelin in the two groups were significantly higher than those before treatment, and the levels of Vaspin were significantly lower than those before treatment. The levels of Vaspin and Ghrelin in the observation group were significantly improved compared with the control group(P＜0.05). 
Conclusion  Liraglutide can effectively regulate blood glucose and serum endothelial cell-related factors Vaspin and Ghrelin levels, and improve vascular endothelial function and cardiac function.

Key words: diabetes melltns, type 2； , coronary heart disease； lillaluin； tigrello