Abstract: Objective  To observe the therapeutic effect and long-term prognosis of interventional occlusion for perimembranous ventricular septal defect(PMVSD) with moderate to severe tricuspid regurgitation. 
Methods  Fifty-three patients with PMVSD complicated by moderate to severe tricuspid regurgitation were selected by echocardiography, and none of them had organic tricuspid valve disease. The therapeutic effect of interventional occlusion for PMVSD and the changes of tricuspid regurgitation were observed. 
Results  PMVSD of all patients was successfully occluded. The area, velocity and pressure difference of tricuspid regurgitation in 52 patients were reduced or decreased with the time of intervention(P＜0.05). One patient had severe tricuspid regurgitation because of occluder intertwined with tendinous cord of tricuspid valve after intervention, and underwent ventricular septal defect repair and tricuspid valvuloplasty. He recovered well after operation. 
Conclusion  After strict preoperative screening, interventional occlusion is safe and effective for some PMVSD patients with moderate to severe tricuspid regurgitation. 

Key words: tricuspid valve insufficiency, heart septal defects, ventricular, ultrasonography, interventional