Abstract: Objective  To analyze the diagnostic value of combined detection of four coagulation  indices and serum tumor markers in hepatitis B-related liver cancer. 
Methods  A total of 20 patients with hepatitis B-related liver cancer(liver cancer group), 35 patients with liver cirrhosis(cirrhosis group), and 76 patients with hepatitis B(hepatitis B group) were selected as the research subjects. The baseline data, hepatitis B virus infection-related indicators, detection results of four coagulation indices［prothrombin time(PT), activated partial thromboplastin time(APTT), thrombin time(TT), fibrinogen(FIB)］, liver function ［total bilirubin(TBIL), alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP), glutamyl transpeptidase(GGT)］, serum tumor markers ［alpha fetoprotein(AFP), carbohydrate antigen 199(CA199), α-L-fucosidase(AFU), thrombin-sensitive protein, tumor necrosis factor-α(TNF-α), vascular endothelial growth factor(VEGF)］ were collected. The receiver operating characteristic curve(ROC) was used to analyze the diagnostic efficiency of four coagulation indices and serum tumor markers. 
Results  The positive rate of HBeAg and HBV-DNA were lower in liver cancer group than in cirrhosis group and hepatitis B group, and lower in cirrhosis group than in hepatitis B group, suggesting significant difference(P＜0.05). TBIL, ALT, ALP and GGT were higher in liver cancer group than in cirrhosis group and hepatitis B group, and higher in cirrhosis group than in hepatitis B group, while AST was lower in liver cancer group than in cirrhosis group and hepatitis B group, and lower in cirrhosis group than in hepatitis B group, with significant difference(P＜0.05). The PT, APTT and TT of liver cancer group were shorter than those of liver cirrhosis group and longer than hepatitis B group. FIB in liver cancer group was higher than that of liver cirrhosis group and lower than that of hepatitis B group. The PT, APTT and TT of liver cirrhosis group were longer, and the FIB was lower, as compared with those of hepatitis B group, suggesting significant difference(P＜0.05). The serum AFP, CA199, AFU, TNF-α, and VEGF levels in liver cancer group were higher than those in cirrhosis group and hepatitis B group; serum AFP in liver cirrhosis group was higher and CA199 and VEGF levels were lower than those in hepatitis B group, with significant difference(P＜0.05). ROC curve analysis showed that four coagulation indices and serum tumor markers alone had predictive value for hepatitis B-related liver cancer(AUC＞0.5). The sensitivity, specificity and accuracy of combined detection of  four coagulation indices and five serum tumor markers were the best, which were 0.83, 0.79 and 0.80 respectively, and AUC was 0.865. 
Conclusion  The four coagulation indices and serum tumor markers have good predictive value for hepatitis B-related liver cancer, which is worthy of clinical promotion and practice.

Key words: liver neoplasms, hepatitis B, four coagulation indices, serum tumor markers