Abstract: Objective To investigate the value and clinical significance of ultrasonic omniview technology combined with serum alpha-fetoprotein(AFP) and peroxiredoxin-2(ApPrx2) in the diagnosis of fetal neural tube defects(NTD). 
Methods A total of 3 107 pregnant women who received regular check-ups in our hospital were selected, including 30 with fetal NTD(observation group) and 3 077 with non-fetal NTD(control group). The fetal NTD detected by ultrasonic omniview technology was calculated, and the general data, serum AFP and ApPrx2 mRNA of the two groups were compared. The Logistic regression equation was used to analyze the related influencing factors of fetal NTD, and the receiver operating characteristic curve(ROC) and area under ROC(AUC) were used to analyze the value of serum AFP and ApPrx2 in the diagnosis of fetal NTD. 
Results Taking clinical follow-up results as the “gold standard”, the sensitivity of ultrasonic omniview technology in diagnosing fetal NTD was 90.00%(27/30), the specificity was 100.00%(3 077/3 077), and the accuracy rate was 99.90%(3 104/3 107). Serum AFP and ApPrx2 mRNA in the observation group were significantly higher than those in the control group(P＜0.05). The Logistic regression equation analysis showed that the risk of fetal NTD in patients with abnormal ultrasonic omniview results was approximately 4.230 times that of normal patients, and the risk of fetal NTD in patients with a history of radiation exposure was approximately 2.897 times that of those without exposure history. The risk of fetal NTD with AFP≥103.96 μg/L was approximately 2.148 times that of those with＜103.96 μg/L, and the risk of fetal NTD with ApPrx2 mRNA≥1.03 was approximately 1.731 times that of those with ApPrx2 mRNA≥1.03(P＜0.05). The AUC of serum AFP and ApPrx2 mRNA to diagnose fetal NTD was 0.863 and 0.900, respectively. 
Conclusion Ultrasonic omniview technology, serum AFP, and ApPrx2 mRNA have certain diagnostic value for fetal NTD. The combination of the three is expected to improve the diagnostic efficiency and is of great value for improving the quality of the birth population. 

Key words: neural tube defect, alpha-fetoprotein, ultrasound examination