Abstract:

Objective  To investigate the efficacy of GeneTime combined with modified vacuum sealing drainage(VSD) in the treatment of refractory wounds and its impact on wound tissue-related growth factors and aesthetic satisfaction.

Methods  A total of 94 patients with refractory wounds were selected and divided into the research group(n=47) and the control group(n=47) according to a simple random number table method. On the basis of conventional treatment, the control group was treated with modified VSD, and the research group was treated with GeneTime on the basis of the control group for a total of 14 d. Therapeutic effects, visual analogue scale(VAS)wound pain score at 7 d and 14 d after treatment, levels of wound tissue-related growth factors［vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF)］ before and at 14 d after treatment, incidence of complications, and aesthetic satisfaction were recorded in the two groups.

Results  The total effective rate of the research group was higher than that of the control group(P＜0.05), and the VAS score of the research group was lower than that of the control group at 7 d and 14 d after treatment(P＜0.05). After treatment, the levels of VEGF and EGF were higher in both groups than those before treatment, and higher in the research group than in the control group(P＜0.05). There was no significant difference in the incidence of complications between two groups(P＞0.05), and the aesthetic satisfaction of the research group was higher than that of the control group(P＜0.05).

Conclusion  The combination of GeneTime and modified VSD has a good effect in the treatment of refractory wounds, with fewer complications, and higher satisfaction of patients.

Key words: wound healing； gene time, modified VSD