Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (5): 574-577.doi: 10.3969/j.issn.1007-3205.2022.05.015

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Effects of cetirizine combined with salbutamol on airway remodeling, PDCD5 and S1P levels in children with acute attack of bronchial asthma

  

  1. 1.Department of Pediatrics, Qingdao Municipal Hospital, Shandong Province, Qingdao 266000, China;

    2.Department of Pediatrics, the People′s Hospital of Qingdao West Coast New Area, Shandong Province, Qingdao 266000, China

  • Online:2022-05-25 Published:2022-05-30

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Abstract:

Objective  To observe the effects of cetirizine combined with salbutamol on airway remodeling, programmed death molecule 5(PDCD5) and sphingosine 1-phosphate(S1P) levels in children with acute attack of bronchial asthma.

Methods  In total,200 children with acute attack of bronchial asthma were selected and randomly divided into control group(n=100) and research group(n=100). The children in the control group were treated with salbutamol, and the children in the research group were treated with cetirizine-assisted salbutamol. Both groups were treated for 7 d. The curative effect and the changes in airway remodeling［osteopontin(OPN), vascular endothelial growth factor(VEGF), matrix metalloproteinase-9(MMP-9), tissue inhibitor of metalloproteinase-1(TIMP-1)］, PDCD5 and S1P levels were compared between two groups. The incidence of adverse reactions during treatment was observed in both groups.

Results  At 7 d after treatment, the total effective rate of the research group was higher than that of the control group(P＜0.05). At 7 d after treatment, the levels of OPN, VEGF, MMP-9, TIMP-1, PDCD5 and S1P in the two groups were lower than those before treatment, while the levels of OPN, VEGF, MMP-9, TIMP-1, PDCD5 and S1P in the research group were lower than those in the control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between two groups(P＞0.05).

Conclusion  Cetirizine combined with salbutamol in the treatment of children with acute attack of bronchial asthma can effectively inhibit airway remodeling and reduce the levels of PDCD5 and S1P. It is a safe and reliable treatment scheme.

Key words: asthma; cetirizine, salbutamol