Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (8): 931-934，955.doi: 10.3969/j.issn.1007-3205.2022.08.013

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The relationship of HPV16 E6, E7 protein levels in cervical cancer tissues with clinical characteristics and prognosis

  

  1. 1.Department of Gynecology, the First Affiliated Hospital of Chengdu Medical College, Sichuan Province, 
    Chengdu 610500, China; 2.Department of Gynecology,  the Affiliated Cancer Hospital of 
    Xinjiang Medical University, Xinjiang Province, Urumqi 830054, China
  • Online:2022-08-05 Published:2022-09-13

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Abstract: Objective To explore the relationship of the levels of human papilloma virus E6 protein(HPV16 E6) and human papilloma virus E7 protein(HPV16 E7) in cervical cancer tissues with the clinical characteristics and prognosis of patients. 
Methods The tumor tissue, adjacent tissue, and normal cervical tissue specimens of 87 patients undergoing radical cervical cancer surgery were selected for research. Immunohistochemistry was used to detect the expression of HPV16 E6 and HPV16 E7 proteins in the tissues for analysis by combining the clinicopathological characteristics of the patients. Kaplan-Meier survival curve was used to compare the 3-year survival of the patients, and the COX regression analysis was used to analyze the effect of various factors on the prognosis of the patients. 
Results Immunohistochemical results showed that the positive rates of HPV16 E6 and HPV16 E7 in tumor tissues were higher than those in adjacent tissues and normal tissues(P＜0.05), and the 3-year survival rate of patients with positive expression of HPV16 E6 and HPV16 E7 protein was lower than that of patients with negative expression(P＜0.05). Multivariate analysis showed that HPV16 E6 and HPV16 E7 were independent risk factors for poor prognosis in patients with cervical cancer(P＜0.05). 
Conclusion HPV16 E6 and HPV16 E7 proteins are positively expressed in cervical cancer tissues, which are related to the clinicopathological characteristics and prognosis of patients, and may play a role as new targets for the treatment of cervical cancer.

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