Abstract: Objective To investigate the effect of high-intensity ultrasound combined with gabapentin on microRNA-19a(miR-19a), microRNA-30b(miR-30b), microRNA-29c(miR-29c) in patients with neuropathic pain. 
Methods A total of 72 patients with neuropathic pain were selected and randomly divided into a control group(n=35) and a combination group(n=37). The control group was treated with gabapentin, and the combination group was treated with high-intensity ultrasound on the basis of the control group. The scores of the National Institute of Health Stroke Scale(NIHSS), modified Barthel index, and the levels of interleukin-6(IL-6), C-reactive protein(CRP), visual analogue scale(VAS) score, neuropathic pain scale(NPS) score, the levels of CD4+, CD8+, CD4+/CD8+, miR-19a, miR-30b and miR-29c, therapeutic effect and occurrence of adverse reactions were compared between two groups. 
Results After treatment, the NIHSS score, IL-6, CRP, VAS score, NPS score, miR-19a, miR-30b and miR-29c expression levels in the two groups were lower than those before treatment, and the levels of improved Barthel index, CD4+, CD8+, CD4+/CD8+ were higher than those before treatment. After treatment, NIHSS score, IL-6, CRP, VAS score, NPS score, miR-19a, miR-30b, and miR-29c expression levels in the combination group were lower than those in the control group, while the levels of modified Barthel index, CD4+, CD8+ and CD4+/CD8+ were higher than those of the control group(P＜0.05). The total effective rate of clinical treatment in the combination group was higher than that in the control group(P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05). 
Conclusion High-intensity ultrasound combined with gabapentin in the treatment of patients with neuropathic pain can significantly improve neurological function and immune function, reduce pain and inflammatory response, and regulate the expression of miR-19a, miR-30b and miR-29c, showing a significant therapeutic effect.

Key words: neuralgia, gabapentin, high-intensity ultrasound