Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (12): 1445-1448.doi: 10.3969/j.issn.1007-3205.2022.12.015

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Expression and significance of vascular endothelial growth factor gene polymorphism in polycystic ovary syndrome

  

  1. 1.Department of Molecular Biology, Cancer Institute of the Fourth Hospital of Hebei Medical University, 
    Shijiazhuang 050011, China; 2.Department of Reproductive Medicine, the Fourth 
    Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • Online:2022-12-25 Published:2023-01-11

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Abstract: Objective To explore the association of single nucleotide polymorphism (SNP)of vascular endothelial growth factor (VEGF) gene rs699947 and rs1570360 SNP with risk of polycystic ovary syndrome (PCOS). 
Methods The association of SNP of VEGF gene rs699947 SNP and rs1570360 SNP with risk of PCOS in 152 PCOS patients and 160 healthy controls was analyzed by polymerase chain reaction-ligase detection reaction (PCR-LDR) method . 
Results The women carrying CC genotype had a higher risk of PCOS compared with the women with the AA genotype. After adjustment of factors, such as age and family history of obesity, OR was 2.896 (95%CI=1.388-6.043). 
Conclusion VEGF gene rs699947 SNP increases the genetic susceptibility of women to PCOS in north China, and the women carrying the CC genotype have a higher risk of PCOS. 


Key words: polycystic ovary syndrome, vascular endothelial growth factor gene, single nucleotide polymorphism