Abstract: Objective To investigate the expression and significance of gastrin-17 (G-17), sex-determining region Y box protein-2 (SOX-2), and heat shock protein 70 (HSP70) in Helicobacter pylori (Hp)-infected gastritis. 
Methods Ninety patients with chronic gastritis were selected and divided into Hp-positive group (n=45) and Hp-negative group (n=45) according to whether they were combined with Hp infection. The general data, G-17 and HSP70 levels and SOX-2 and HSP70 expressions of the two groups were compared. The correlation between G-17, SOX-2 and HSP70 in Hp-positive patients with various indexes was analyzed. Multivariate logistic regression analysis was performed to analyze risk factors for Hp-infected gastritis. 
Results The proportion of shared meals and clinical symptom scores in the Hp-positive group were higher than those in the Hp-negative group, and the levels of pepsinogen Ⅰ (PG-Ⅰ) and pepsinogen Ⅱ (PG-Ⅱ) were lower than those in the Hp-negative group (P＜0.05). The G-17 level in the Hp-positive group was lower than that in the Hp-negative group, while the expression  level of HSP70, SOX-2 positive and HSP70 positive expression were higher than those in the Hp-negative group (P＜0.05). In Hp-positive patients, G-17 was positively correlated with PG-Ⅰ and PG-Ⅱ and negatively correlated with clinical symptom scores, while SOX-2 and HSP70 were negatively correlated with PG-Ⅰ and PG-Ⅱ and positively correlated with clinical symptom scores (P＜0.05). The results of logistic regression analysis showed that dietary style, PG-Ⅱ, G-17, SOX-2 and HSP70 were risk factors affecting patients with Hp-infected gastritis (P＜0.05). 
Conclusion G-17 is low in patients with Hp-infected gastritis, while positive expression of SOX-2 and HSP70 is higher, and dietary style, PG-Ⅱ, G-17, SOX-2 and HSP70 are risk factors affecting patients with Hp-infected gastritis. 

Key words: gastritis, gastrin-17, sex-determining region Y box protein 2, heat shock protein 70