Abstract: Objective To investigate the effect of alendronate sodium combined with calcium supplements in preventing secondary fractures after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures(OVCF). 
Methods In total, 128 patients with OVCF undergoing PVP were selected. According to different antiosteoporosis medication schemes after operation, patients were divided into the control group (calcium carbonate D3+calcitriol, n=71) and the research group (calcium carbonate D3+calcitriol+alendronate sodium, n=57). The bone metabolic indicators, imaging parameters and incidence of secondary vertebral fracture in the two groups during different periods were analyzed.  
Results The levels of serum type Ⅰ collagen carboxy terminal peptide β special sequence （β-CTX） and type Ⅰ procollagen N-terminal prepetide (PINP) in both groups showed a downward trend with time, and the downward trend of the research group was more obvious than that of the control group; There were significant differences in the interaction between groups, time points, and time points between groups (P＜0.05). The height ratio of the anterior edge of the injured vertebral body, the Cobb angle in the sagittal plane, and the bone density of the femoral neck in both groups showed an increasing trend with time. The increasing trend in the research group was more obvious than that in the control group, and there were significant differences in the interaction between groups, time points, and time points between groups (P＜0.05).The total incidence of postoperative secondary fracturesof vertebral body in the research group was lower than that in the control group (P＜0.05). 
Conclusion Combination of alendronate sodium and calcium supplements can improve bone metabolism, increase bone mineral density, and reduce the incidence of secondary vertebral fractures in patients undergoing PVP. Therefore, it is worthy of clinical promotion. 

Key words: vertebroplasty, alendronate sodium, calcium supplements