Journal of Hebei Medical University ›› 2023, Vol. 44 ›› Issue (10): 1141-1145.doi: 10.3969/j.issn.1007-3205.2023.10.005

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Relationship between peripheral blood NF-κB, IL-34, CCL18 levels and prognosis in patients with AECOPD

  

  1. 1.The Fourth Department of Respiratory Diseases, Hebei Chest Hospital, Shijiazhuang 050000, China； 
    2.The First Department of Respiratory Diseases, Hebei Chest Hospital, Shijiazhuang 050000, 
    China； 3.Department of Infectious Diseases， Hebei Chest Hospital, Shijiazhuang 
    050000, China； 4.The Fifth Department of Tuberculosis, 
    Hebei Chest Hospital, Shijiazhuang 050000, China

  • Online:2023-10-25 Published:2023-11-03

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Abstract: Objective To explore the relationship of peripheral blood nuclear transcription factor-κB (NF-κB), interleukin-34 (IL-34) and chemokine ligand 18 (CCL18) with the prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). 
Methods In total, 100 patients with AECOPD were selected as the AECOPD group, 100 patients with stable chronic obstructive pulmonary disease (SCOPD) were selected as the SCOPD group, and 100 healthy physical examinees were selected as the control group. The levels of NF-κB, IL-34, and CCL18 in peripheral blood of each group were detected, and the predictive value of peripheral blood NF-κB, IL-34, and CCL18 levels for the death of AECOPD patients during hospitalization was analyzed. 
Results The levels of NF-κB, IL-34 and CCL18 in peripheral blood in AECOPD group and SCOPD group were higher than those in control group, and the levels of NF-κB, IL-34 and CCL18 in peripheral blood in AECOPD group were higher than those in SCOPD group (P＜0.05). High levels of NF-κB, IL-34, and CCL18 in peripheral blood were risk factors for the occurrence of AECOPD (P＜0.05), and the risk of AECOPD in patients with high levels of NF-κB, IL-34, and CCL18 in peripheral blood was 4.165 times, 4.012 times, and 4.027 times higher than that in patients with low levels. The peripheral blood NF-κB, IL-34, CCL18 levels and acute physiology and chronic health evaluation (APACHE) Ⅱ scores of AECOPD patients who died during hospitalization were higher than those of surviving patients during hospitalization (P＜0.05). The levels of NF-κB, IL-34, CCL18 in peripheral blood of AECOPD patients were positively correlated with APACHE Ⅱ scores (P＜0.05). The combined detection of NF-κB, IL-34, and CCL18 levels in peripheral blood in predicting the death of AECOPD patients during hospitalization had the largest area under the receiver operating characteristic (ROC) curve, which was 0.933. 
Conclusion The levels of NF-κB, IL-34 and CCL18 in peripheral blood of patients with AECOPD are significantly increased, and the elevated levels are closely related to the prognosis of patients. Clinical detection of NF-κB, IL-34 and CCL18 levels can effectively predict the prognosis of patients with AECOPD. 


Key words: pulmonary disease, chronic obstructive, NF-kappa B, interleukin-34, chemokine CCL18