Abstract: Objective To investigate the effect of Nd:YAG laser therapy on visual acuity and diopter improvement, clinical effect and prognosis of patients with capsular contraction syndrome (CCS) after cataract surgery. 
Methods A total of 200 patients (220 eyes) with CCS were selected as the research objects, and divided into the experimental group (109 patients, 112 eyes) and the control group (91 patients, 108 eyes) according to random number table method. The control group underwent surgical dissection of the anterior capsule opening, and the experimental group received Nd:YAG laser treatment. Best corrected visual acuity (BCVA), diopter, intraocular pressure (IOP) and macular volume(MV), diameter of capsule opening and ocular residual astigmatism were compared between two groups before treatment and at 1 week after treatment. Patients in both groups were followed up at 1 month after surgery to analyze the incidence of complications. 
Results At 1 week after treatment, the visual acuity, diopter, IOP, MV, diameter of capsule opening and ocular residual astigmatism of the two groups were better than those before treatment, and the visual acuity, diopter, IOP, MV, diameter of capsule opening and ocular residual astigmatism of the experimental group were better than those of the control group (P＜0.05). The overall complication rate of experimental group was lower than that of control group (P＜0.05). 
Conclusion Nd:YAG laser therapy for CCS patients can effectively improve visual acuity and diopter, maintain IOP and macular volume, and alleviate capsular contraction, which has a positive impact on prognosis and has certain safety in clinical practice. 

Key words: capsular contraction syndrome, cataracts, Nd:YAG laser technique