Abstract: Objective To investigate the insulin secretion, serum 25 hydroxyvitamin D3 ［25 (OH) D3］, neutrophil to lymphocyte ratio (NLR), serum uric acid (SUA) levels and clinical significance in patients with type 2 diabetes mellitus (T2DM) accompanied by sudomotor dysfunction.〖KG*2〗
Methods In total, 97 patients with T2DM and sudomotor dysfunction treated in our hospital were selected as the observation group, and 194 patients with T2DM but without sweating nerve dysfunction were selected as the control group with a gender ratio of 1〖DK〗∶2. The differences in clinical data, islet function, 25 (OH) D3, NLR and SUA levels between the two groups were analyzed and compared. The factors affecting T2DM combined with sudomotor dysfunction were analyzed by Logistic regression analysis. 
Results The age and duration of diabetes in the observation group were (58.32±9.94) years and (11.41±2.84) years respectively, which were significantly higher than those in the control group (P＜0.05). The ratio of net increase in C-peptide to glucose (ΔC-P30/ΔG30), the ratio of net increase in insulin to glucose (ΔI30/ΔG30), the area under the curve of insulin (I-AUC/G-AUC) and the AUC of corrected C-peptide under 120 min blood glucose (C-P-AUC/G-AUC) in the observation group were (0.22±0.13), (1.55±0.36), (0.09±0.03) and (2.87±0.90), respectively, which were significantly lower than those in the control group (P＜0.05). The serum 25 (OH) D3 in the observation group was (22.12 ± 6.01) μg/L, which was significantly lower than that in the control group (P＜0.05), while the NLR and SUA were (3.12±0.94) and (365.50±90.48) μmol/L, respectively, which were significantly higher than those in the control group (P＜0.05). Logistic regression analysis showed that age, course of diabetes, ΔC-P30/ΔG30, 25 (OH) D3, NLR and SUA were the influencing factors for the sudomotor dysfunction (P＜0.05). 
Conclusion Patients with T2DM and sudomotor dysfunction have impaired insulin secretion, decreased serum 25 (OH) D3, and increased NLR and SUA levels. T2DM combined with sudomotor dysfunction is affected by early phase pancreatic secretion function and serum 25 (OH) D3, NLR, and SUA levels, which warrants further studies.

Key words: diabetes mellitus, type 2, insulin secretion, sudomotor dysfunction