Abstract: Objective To compare the application value of polyether-ether-ketone (PEEK) interbody fusion device and autogenous iliac bone in the treatment of lumbar disc herniation by transforaminal lumbar interbody fusion (TLIF). 
Methods Seventy patients with lumbar disc herniation who underwent TLIF were selected as the research subjects. The patients were divided into two groups by random number table method. Thirty-five patients in the observation group were treated with autogenous iliac bone and 35 patients in the control group were treated with PEEK interbody fusion device. The intraoperative blood loss, duration of operation, duration of hospital stay and complication rate of the two groups were observed. The visual analogue scale (VAS) score, Oswestry disability index (ODI) and intervertebral space height of the two groups were compared before operation and at different time points after operation, and the fusion rate of bone graft after operation was compared between the two groups. 
Results The intraoperative blood loss and duration of operation in the observation group were significantly higher than those in the control group (P＜0.05), and there was no significant difference in duration of hospital stay and incidence of complications between the two groups (P＞0.05). The VAS scores of both groups decreased with the passage of time before and after operation, and there was a significant difference between different time points (P＜0.05); however, there was no significant difference in the interaction between groups and time points (P＞0.05). The ODI scores of the two groups decreased with the passage of time before and after operation, and the difference between time points was statistically significant (P＜0.05). However, there was no significant difference in the interaction between groups and time points (P＞0.05). The preoperative intervertebral space height of the two groups first increased and then decreased with the passage of time before and after operation, and the difference of interaction between time points was statistically significant (P＜0.05); however, there was no significant difference in the interaction between groups and time points (P＞0.05). The bone graft fusion rate in the observation group was higher than that in the control group at 3 months and 6 months after surgery (P＜0.05), and there was no significant difference in the bone graft fusion rate at 12 months after surgery (P＞0.05).
Conclusion Both autogenous iliac bone and PEEK interbody fusion device can effectively treat lumbar disc herniation during TLIF surgery, but the fusion rate of autogenous iliac bone in the early stage of treatment is more advantageous.

Key words: intervertebral disc displacement, intervertebral fusion device, transforaminal interbody fusion