Journal of Hebei Medical University ›› 2024, Vol. 45 ›› Issue (12): 1387-1393.doi: 10.3969/j.issn.1007-3205.2024.12.005

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Association between remnant cholesterol level and body mass index in patients with acute ischemic stroke

  

  1. 1.Department of Neurology, the First Affiliated Hospital of Northwest University, Xi′an No.1 Hospital, Shanxi Province, Xi′an, 710002 China; 2.Department of Epidemiology and Biostatistics, School of Public Health, Xi′an Jiaotong University Health Science Center, Shanxi Province, Xi′an 710061, China

  • Online:2024-12-25 Published:2025-01-03
  • Supported by:
    陕西省科技计划项目(2023-YBSF-041,2022SF-381,2022SF-507和2023-YBSF-052)；陕西省中医药管理局项目（2022-SLRH-LJ-013）；西安市科技计划项目(22YXYJ0061和22YXYJ0074)；西安市卫生健康委员会科研项目(2021yb33和2022qn11)

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Abstract: Objective To investigate the association between remnant cholesterol (RC) levels and body mass index (BMI) in patients with acute ischemic stroke (AIS). 
Methods Based on the Stroke Registry Study database platform, clinical baseline data and laboratory test results of AIS patients admitted to four grade-A tertiary hospitals in Xi′an City from January to December 2017 were retrospectively analyzed. Patients with AIS were divided into four groups according to BMI: low weight group (BMI <18.5), normal body mass group (BMI: 18.5-23.9), overweight group (BMI: 24.0-27.9) and obese group (BMI≥28.0), and compared differences in clinical characteristics in different BMI groups. Multivariate regression analysis was used to investigate the association between different BMI and RC levels in patients with AIS, which was further explored by stratifying according to age and gender. 
Results A total of 2 059 patients with AIS were finally included, with a mean age of (64.3±12.4) years, including 1 575 (62.8%) males and 934 (37.2%) females. After adjusting for relevant confounders, multivariate regression analysis showed that RC level was 0.13 mmol/L higher in AIS patients in obese group compared with normal weight group (β=0.13, 95%CI:0.02-0.23, P=0.015), and the trend of RC level increasing with the increase of BMI was statistically significant (P=0.033). Stratified analysis according to age revealed that the RC level was 0.23 mmol/L higher in obese AIS patients aged 45-65 years compared with normal weight patients (β=0.23, 95%CI: 0.06-0.40, P=0.009),and elderly AIS patients aged ≥65 years with low weight had a 0.14 mmol/L lower RC level than those with normal body weight (β=-0.14, 95%CI: -0.26--0.03, P=0.017).Stratified analysis by gender revealed that RC levels were significantly higher in obese AIS patients compared to normal body weight only in men (β=0.16, 95%CI: 0.02-0.31, P=0.028), but there was no significant correlation between RC and normal weight in women. 
Conclusion The level of RC is significantly increased in middle-aged and elderly obese male patients with AIS，which may be related to the prognosis of these patients, and warrant the attention of clinicians.