Journal of Hebei Medical University

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ThecurativeeffectandinfluenceofserumhsCRPandVEGFofpatientswithischemic#br# cardiomyopathyandheartfailurewithSofrenInjection

  

  1. 1. DepartmentofSecondCardiology , thePeople'sHospitalofFengrunDistrict , TangshanCity ,
    HebeiProvince , Tangshan 064000 , China ; 2. DepartmentofPreventiveMedicine , theSchoolof
    PublicHealth , NorthChinaUniversityofScienceandTechnology , Tangshan 063000 , China ;
    3. DepartmentofClinicalLaboratory , thePeople ' sHospitalofFengrunDistrict ,
    TangshanCity , HebeiProvinc , Tangshan 064000 , China
  • Online:2016-02-25 Published:2016-04-27

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Abstract:  Objective Toexplorethecurativeeffectandsignificanceofserum high-
sensitivityC-reactiveprotein ( hsCRP ) andvascularendothelialgrowthfactor ( VEGF ) ofpatients
withischemic cardiomyopathy and heartfailure with Sofren injection , to investigateits
pharmacologicaleffects.Methods Onehundredandtwentypatientswererandomlydividedinto
twogroups , 59casesasSofrengroupand61casesascontrolgroup.Thetwogroupsweregiven
conventionaltherapy.TheSofrengroupwasgivenSofrenInjection10 mL / dintravenousdrip
basedonroutinetreatment.Thetwogroupsweretreatedfor2 weeks.Thenleftventricular
ejectfraction ( LVEF ), leftventricularinternaldiameteratend-diastole ( LVIDd ) andthecontent ofserumB-typenatriureticpeptide ( BNP ), hsCRPandVEGFofthetwogroupswereanalyzed.
Results Comparedwiththepretreatment , thecontentofserumBNPandhsCRPoftheSofren
groupandthecontrolgroup weredecreased ( P <0.05 ), LVEFandtheserum VEGF were
increased ( P <0.05 ), LVIDdofthesafrengroupwasdecreased ( P <0.05 ), buttherewasno
significantdifferenceinLVIDdwiththecontrolgroup ( P >0.05 ) .LVIDdandcontentofserum
BNPandhsCRPofSofrengroupwerealllowerthanthoseofcontrolgroupafter2weeksof
treatment ( P <0.05 ), LVEFandthecontentofserum VEGF wereallhigherthanthoseof
controlgroupafter2weeksoftreatment ( P <0.05 ) .Conclusion SofrenInjectioncanimprove
thesymptomsofpatientswithischemiccardiomyopathandheartfailure , decreasethecontent
serumBNPandhsCRPquickly , increaseLVEFandthecontentserum VEGF.Themechanism
mayberelatedtotheblockinginflammatoryreactionofatherosclerosis.

Key words: heartfailure , Sofren , C-reactiveprotein , vascularendothelialgrowthfactors