Abstract: [ Abstract ] Objective To establish a new method for determination of ranitidine
hydrochloridedrugcontent.Methods Byusingranitidinehydrochlorideastemplate , andusingo-
pheny-lenediamineaswellasmethacrylicacidasfunctionalmonomer , wepreparedthemolecular
imprintedpolymermembranesensorofranitidinehydrochlorideonthesurfaceofaglassycarbon
electrodeby using cyclic voltammetry ( CV ) electropolymerization method.Electrochemical
behaviorofthesensorwascharacterizedbyCV anddifferentialpulsevoltammetries ( DPV ) .
Results ThepeakcurrentsofDPVandconcentrationhaveagoodlinearrelationshipintherange
of3. 010×10
-7 -6.
172×10
-6
mol
/ L , andthelinearequationwasIp (
μ A ) =-2.
423c+0. 00002
(
r =0.9951 ) .Conclusion Thesensordisplayedgoodselectivity , excellentreproducibility ,
stability , accuracy , anditcouldbeusedtomeasureranitidinehydrochloridedrugactualcontent.

Key words: ranitidine； molecular imprinting, cyclic voltammograms； electrode