Abstract: ［Abstract］  Objective〖HTSS〗〓To investigate the compatible stability of Azithromycin Lactobionate for injection with budesonide and ambroxol hydrochloride for injection.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Basing on clinical medication methods, azithromycin lactobionate, budesonide, ambroxol hydrochloride were prepared to compatibility solution with 0.9% sodium chloride injection. The contents of three drugs within 7 days were determined by liquid chromatographymass spectrometry/mass spectrometry（LCMS/MS）. The appearance and pH value of mixture were investigated.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The contents of azithromycin lactobionate, budesonide and ambroxol hydrochloride changed less than 5% within 2 days, and the contents of three drugs was equal to 70%-90% of 0 h at 3 days, the contents of three drugs decreased significantly after 3 days, only less than 50% of 0 h. When azithromycin lactobionate and budesonide were put in different compatible solutions and stored at different temperatures, the concentration of azithromycin and budesonide were decreased. There was statistical significance difference between time points(P＜005), but there was no significant difference between groups(P＞005), and the interaction between groups and time(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Azithromycin lactobionate, budesonide and ambroxol hydrochloride are compatible, should be preserved at room temperature, and should not exceed 3 days for nose drops use.

Key words: azithromycin, budesonide, ambroxol, drug stability