Abstract: ［Abstract］Objective〖HTSS〗〓To investigate the drug resistance status and trends of acinetobacter baumannii from our hospitalized patients between January 2013 and June 2015 so as to provide references for guiding reasonable application of antibiotics clinically.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The drug resistance rates of acinetobacter baumannii and defined daily dose(DDDs) used eight kinds of antimicrobial drug were retrospectively analyzed. Meanwhile, nonlinear relationship was estimated by regression.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Acinetobacter baumannii has a high resistance to a variety of commonly used antimicrobial agents. It is significantly positively correlated with the consumption of meropenem(r=0.667, P=0.035) and negatively correlated with the consumption of cefepime(r=-0.736,P=0.015). There was no correlation between the resistance rate of acinetobacter baumannii and DDDs of piperacillin sodium/he azole sodium, imipenem/cilastatin, cefoperazone/sulbactam, ceftazidime, levofloxacin, ciprofloxacin（P＞005）. 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓There is a certain correlation between the use of antibacterial drugs and the rate of bacterial resistance. Antibiotics should be used rationally in accordance with clinical sensitivity test results as far as possible. The cefoperazone/sulbactam and cefepime are the better options to treat acinetobacter baumannii infection in our hospital.

Key words: acinetobacter baumannii, antibacterial drugs, drug resistance rate