Abstract: ［Abstract］ Objective〖HTSS〗〓To observe the security and the clinical effects of calcitriol combined with valsartan on patients with diabetic nephropathy（DN）.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty patients with DN were randomly divided into two groups (control group and observation group). The control group were given valsartan and the observation group were given calcitriol and valsartan. Before and after treatment for six months. 24hour urinary protein quantification（UTP), urinary albumin excretion rates(UAER), highsensitive Creactive protein（hsCRP）, kalium(K), calcium(Ca), phosphorus(P), serum creatinine(SCr）, parathyroid hormone(PTH) were detected.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓UTP, UAER, hsCRP of the patients in the two group after treatment was significantly decreased, the difference was statistically significant（P＜005）. After treatment, the UTP, UAER and hsCRP in the observation group were lower than those in the control group（P＜005）. PTH in the 2 groups before and after treatment did not change significantly, the difference between the 2 groups before treatment and after treatment were not statistically significant（P＞005）.  K， Ca， P， SCr in the 2 groups were no obvious change before and after treatment. The difference was not statistically significant (P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Calcitriol combined with valsartan can effectively reduce the urinary albumin excretion rate of patients with diabetic nephropathy,and the curative effect is better than alone.

Key words: diabetic nephropathy, calcitriol, valsartan, vitamin D