Abstract: ［Abstract］  Objective〖HTSS〗〓To evaluate the outcome of reduplicative intravenous administration combined with intraarticular injection of tranexamic acid(TXA) in primary total hip arthroplasty(THA).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Total of 92 patients, accepting primary total hip arthroplasty, were divided into experiment group(intravenous administration of TXA 15 mg/kg before incision, intraarticular injection of TXA 1.0 g intraoperation, intravenous administration of TXA 10 mg/kg 3 hours postoperation, n=46) and, control group (intravenous administration of TXA 15 mg/kg before incision, intraarticular injection of TXA 1.0 g intraoperation, n=46）. Postoperative evaluation index include bleeding volume, transfusion volume and complications as well as variation of hemoglobin and blood volume, erythrocrit, and hospital stays.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Three days after operation, no deep venous thrombosis(DVT) was found among all patients through ultrasounds. Both experiment group and control group have one patient receving transfusion with the volume of 400 mL. There was no significant difference between the two groups in intraoperative bleeding volume, haematocrit and hospital stay. However significant differences were found in postoperative bleeding volume and hemoglobin content between the two groups(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓〖JP2〗Postoperative bleeding volume was significantly decreased in primary THA with reduplicative intravenous administration combined with intraarticular injection of TXA.

Key words: arthroplasty, replacement, hip, tranexamic acid, hemorrhage