Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the correlation between heart rate variability(HRV) and plasma homocysteine(Hcy) in patients with ischemic stroke.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Among the patients in neurology department, ninetyfour cases that were diagnosed as ischemic stroke according to the imaging examination were colleted into case group, and eightytwo healthy volunteers for medical examination in our hospital were selected into control group. Neurological scores of case group were evaluated by the National Institutes of Health Stroke Scale(NIHSS), Hcy levels of both groups were tested by routine detection of enzyme linked immune method, and shortrange 5 min of HRV monitoring and HRV indices recording were conducted by spectrum analysis technology. We compared the Hcy levels and HRV values in two groups, and analyzed the relationship between Hcy, HRV and NIHSS in case group.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①Compared with the control group, Hcy levels of case group was significantly higher(P＜005). ②Compared with the control group, HRV time domain index RR interval standard deviation(SDNN), rootmeansquare successive difference(RMMSD), the percentage value of NN50 count(PNN50), low frequency(LF), high frequency(HF) of case group were all significantly decreased(P＜005), and the frequency domain index that reflects sympathovagal balance index(LF/HF) increased significantly(P＜005). ③NIHSS score in case group was positively correlated with LF/HF, and negatively correlated with all the other index of HRV. ④Hcy level in case group was positively correlated with LF/HF, and had a negative correlation with other indicators of HRV.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The level of Hcy and HRV are abnormal in the patients with acute ischemic stroke. Variation of HRV increases with aggravation of neurologic defect, and is closely related to the level of Hcy.

Key words: stroke, heart rate viability, homocysteine