Abstract: ［Abstract］ Objective〖HTSS〗〓 To investigate the dynamic change rule and prognostic significance of white blood cell（WBC）, erythrocyte sedimentation rate（ESR）, procalcitonin（PCT） and creactive protein（CRP） in the treatment of early infection after fracture surgery by retaining internal fixation while using vacuum sealing drainage（VSD）.  
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 45 patients with deep infection after internal fixation were treated by VSD. WBC, ESR, PCT and CRP were recorded before and 1, 3, 7, 14 and 21 days after operations. The results were divided into cured group and noncured group according to whether the patients were cured or not. The selfcontrol study within the group and the intergroup control study were carried out.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference in the interaction of WBC in group, time, group·time between the cured group and the noncured group(P ＞005). ESR in both groups was increased slightly after operation, and decreased gradually after the peak on the 3 rd day. There were significant differences in the interaction among group, time, group·time(P＜005). PCT was decreased both in the cured group and the noncured group, and there were significant differences in the interaction among group, time, and group·time(P＜005). CRP in the cured group reached the peak on 3rd day after operations, and then was decreased; The level of CRP was increased significantly in the noncured group as time increases, and there were significant differences in the interaction among group, time, and group·time(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓CRP were raised early after operation, and continued to rise, suggesting that preserving internal fixation and curing the infection after internal fixation was less possibility. Removal of internal fixation should be considered and other therapies should be used. WBC did not change significantly within 3 weeks after operation, and was not recommended for early prognosis.

Key words: fractures, bone, vacuum sealing drainage； Creactive protein, erythrocyte sedimentation rate