Abstract: ［Abstract］〓Objective〖HTSS〗〓To explore the correlation between pulmonary emphysema and pulmonary function test(PFT) in different pathological types of chronic obstructive pulmonary disease(COPD).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 42 patients with clinically confirmed COPD emphysema were selected. In the present study，pulmonary emphysema was divided into the following 2 subtypes according to MSCT feature: centrilobular emphysema(CLE) group(n=28)and panlobular emphysema(PLE)group(n=14). The percentage of lower attenuation voxel volume(LAV%) was automatically measured with quantitative analysis software which was pulmonary emphysema index for the total lung and each lobar. The forced expiratory volume in 1 second predicted(FEV1%), the ratio of forced expiratory volume in 1 second over forced vital capacity(FEV1/FVC) , the ratio of residual volume to total lung capacity ratio(RV/TLC) and percentage of the diffusing capacity for carbon monoxide per literof lung volume predicted value（DLco%） were measured using spirometer.The correlation between LAV% and PFT index were analyzed in 42 patients with emphysema.LAV% and PFT index were compared between different groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓LAV% of both lung and each lobar in CLE group was statistically lower than PLE group( P＜005)，and DLco% of both lung and each lobar in CLE group was statistical higher than PLE group(P＜005). There were no difference between CLE and PLE groups for FEV1%, FEV1/FVC and RV/TLC(P＞005) . LAV% of both lungs ，left lung，right lung and each lobar were negatively correlated with FEV1/FVC(P＜005）. Apart from right middle lobar，LAV% of both lungs，left lung，right lung and each lobar were negatively correlated with DLco%（P＜005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓DLco% in CLE group was statistically higher than PLE group. LAV% were correlated with the PFT index. The subtype according to the CT features was helpful for the individualized treatment of pulmonary emphysema in COPD.

Key words: pulmonary disease, chronic obstructive, pulmonary emphysema, respiratory function tests