Abstract: ［Abstract］ Objective〖HTSS〗〓To study the effect of high resolution CT(HRCT) combined with serum tumor markers in the diagnose of solitary pulmonary nodule(SPN).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 126 cases of malignant SPN patients were selected as observation groups, 98 cases of benign SPN patients from the same time were selected as control group. They were detected by HRCT and serum carcinoembryonic antigen(CEA), squamous cell carcinoma antigen(SCC), neuronspecific enolase(NSE), cytokeratin 19 fragment(CYFRA211) detection separately, the pathological diagnosis result were set as gold standard. Any of the HRCT detection or tumor markers positive was regarded as joint detection positive, ROC curve was used to evaluate single detection and joint detection diagnostic efficacy.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The two groups had significant differences in the detection rate of deep lobulation, bronchovascular convergence sign, short fine spiculation, adjacent pleural thickening, pleural indentation, polycystic light shadows, spinous processes and satellite lesions, etc(P＜005). The sensitivity was 7857%, the specificity was 8980%, diagnosis accuracy was 8348%. The serum CEA, SCC, NSE, CYFRA211 of observation group were significantly higher than control group, the sensitivity was 5317%, the specificity was 8878%, the accuracy was 6518%. The sensitivity of joint detection was 9206%, which was significantly higher than single detection（P＜005）. The specificity was 7142%, which was significantly lower than single detection（P＜005）. The accuracy, the positive predictive value and the negative predictive value were 8304%, 8056%, and 8750%, respectively. The area under ROC curve of joint detection was 0869, which was significantly higher than single detection 0745 and 0707（P＜005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Joint detection of HRCT combined with serum tumor markers can be applied in the detection of SPN, which can significantly improve the sensitivity and diagnosis efficacy, and with a good specificity, with is worth of applying.

Key words: solitary pulmonary nodule, high resolution CT； tumor markers