Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the clinical effect and electrophysiological changes of intravenous drip of human immunoglobulin combined with mechanical ventilation nerves and muscles in children with severe GuillainBarre syndrome treated by highdose intravenous drip of human immunoglobulin combined with mechanical ventilation.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Selection of 34 patients with severe GuillainBarre syndrome. All the patients were treated with routine treatment, pulse therapy with highdose intravenous immunoglobulin(IVIG) and mechanical ventilation. Observation of clinical efficacy, especially neurological function.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After the treatment, the clinical score of nerve function in the patient was significantly lower than before the treatment, and the conduction speed of the median nerve, fibular nerve, ulnar nerve, limb pain and tibial nerve was significantly higher than before the treatment(P＜005). After treatment, the abnormal rate of myoelectric examination was significantly lower than before treatment, and the loss of nerve potential was significantly different before treatment. The transport unit potential raising type significantly decreased the pure type and pathological electrostatic type, the interference wave decreased, and the total interference type increased significantly compared to the pretreatment(P＜005). Patients with limb weakness, muscle tension recovery, respiratory paralysis, tendon reflex recovery,  and sensory disorders use time are all shorter. After treatment, there was one patient who had no autonomous breathing, had difficulty withdrawing, and parents gave up treatment and eventually died.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The combined mode of mechanical ventilation and IVIG can remarkably increase the clinical efficacy, shorten the course of the disease and improve the nerve damage. It is worthy of clinical promotion.

Key words: GuillainBarre syndrome； immunoglobulins, intravenous, neural conduction