Abstract: ［Abstract］Objective〖HTSS〗To screen the active ingredients of Xiebai Syrup and to explore its core targets and mechanism for the treatment of cough.
〖HTH〗〖WTHZ〗Methods〖HTSS〗Network pharmacology methods were employed. The active ingredients of the Xiebai Syrup were found and screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) and literature. Gene targets related to cough were searched using the Therapeutic Target Database(TTD), the Genetic Association Database(GAD), and the Pharmacogenetics and Pharmacogenomics Knowledge Base(PharmGKB) database and normalized by the Uniprot database. Protein interaction networks was constructed with Cytoscape 3.7.1 software in order to find core targets. The Metascape database was used to analyze Gene Ontology of the core targets.
〖HTH〗〖WTHZ〗Results〖HTSS〗Fiftyfour core targets were screened and 20 main pathways related with cough were found, involving response to endoplasmic reticulum stress, immune responseactivating signal transduction and so on.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗This study reflected the “multicomponent, multitarget, multipathway” characteristics of Xiebai Syrup, which provides a theoretical basis of the clinical use of Xiebai Syrup.

Key words: cough, Xiebai Syrup, network pharmacology